Nisbet N W, Menage J, Loutit J F
Transplantation. 1979 Oct;28(4):285-90. doi: 10.1097/00007890-197910000-00004.
Osteopetrotic microphthalmic mice (mi/mi) were treated by injections of suspensions of myeloid tissue, newborns i.p., and weanlings i.v. Donated syngeneic material effected permanent cure of oteopetrosis provided that the dose was large enough (10(8) cells of bone marrow). H-2-compatible allogeneic bone marrow was initially as effective, but relapse ensued in immunocompetent mice. H-2-incompatible marrow was ineffecitve except in one set of newborn tolerant mice. Total body X-radiation in sublethal doses to recipients allowed permanent cure with H-2-compatible, and, in one circumstance, with H-2-incompatible marrow in smaller doses. The best results were obtained after lethal irradiation and the smaller dose of marrow. Results were checked by chromosome assay demonstrating that cure or relapse was correlated with permanent take or rejection, respectively, of a transplant in a recipient's bone marrow. Retention of donor lymphocytes alone was not associated with effective bony resorption; the candidate cell line for effectiveness remains the haematopoietic stem cell-monocyte-tissue phagocyte.
骨石化性小眼小鼠（mi/mi）通过腹腔注射骨髓组织悬液治疗新生小鼠，并通过静脉注射治疗断奶小鼠。只要剂量足够大（10⁸个骨髓细胞），捐赠的同基因物质就能使骨石化症得到永久性治愈。H-2相容的同种异体骨髓最初同样有效，但免疫功能正常的小鼠会出现复发。H-2不相容的骨髓无效，除非是一组新生的耐受小鼠。对受体进行亚致死剂量的全身X射线照射，使用H-2相容的骨髓以及在一种情况下使用较小剂量的H-2不相容骨髓可实现永久性治愈。致死性照射和较小剂量的骨髓治疗后效果最佳。通过染色体分析检查结果，表明治愈或复发分别与受体骨髓中移植的永久性植入或排斥相关。仅保留供体淋巴细胞与有效的骨吸收无关；有效的候选细胞系仍然是造血干细胞-单核细胞-组织吞噬细胞。
