Bartholow L C, Geyer R P
Biochemistry. 1982 Mar 16;21(6):1271-3. doi: 10.1021/bi00535a025.
Sterol release from strain L fibroblasts was measured in serum-free medium supplemented with delipidated human serum albumin and various phospholipids. The sterol molecule appears to preferentially interact with the sn-2-acyl chain of the phospholipid. The carbonyl oxygen of the phospholipid acyl ester linkage is not required for sterol-phospholipid interactions, while the phosphate and choline groups are required. In the presence of the human serum albumin-phospholipid complex, phospholipids containing trans-acyl groups are significantly more effective at removing cellular sterol than the corresponding cis-acyl group.
