[反应过程中的酶失活。动力学描述及机制判别]
[Enzyme inactivation in the course of the reaction. Kinetic description and discrimination of mechanisms].
作者信息
Varfolomeev S D
出版信息
Biokhimiia. 1982 Mar;47(3):343-54.
PMID:7074166
Abstract
The kinetic regularities of the enzymatic reaction involving substrate depletion and enzyme inactivation were studied. Various inactivation mechanism including monomolecular inactivation of the free enzyme or the enzyme--substrate complex and bimolecular inactivation with the substrate and reaction product were investigated. The possibility of discrimination of these mechanisms and determination of the kinetic parameters for these processes based on integral equations are discussed.
摘要
研究了涉及底物消耗和酶失活的酶促反应的动力学规律。研究了各种失活机制，包括游离酶或酶-底物复合物的单分子失活以及与底物和反应产物的双分子失活。讨论了基于积分方程区分这些机制并确定这些过程动力学参数的可能性。
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