Boivin J F, Hutchison G B
Cancer. 1982 Jun 15;49(12):2470-5. doi: 10.1002/1097-0142(19820615)49:12<2470::aid-cncr2820491210>3.0.co;2-y.
The authors conducted a study designed to evaluate the hypothesis that irradiation to the heart in the treatment for Hodgkin's disease (HD) is associated with increased coronary heart disease (CHD) mortality. This report describes 957 patients diagnosed with HD in 1942-75 and analyzes follow-up findings through December 1977. Twenty-five coronary heart disease deaths have been observed, and 4258.2 person-years of experience at risk have been accrued. The relative death rate (RDR), defined as the CHD mortality for heart-irradiated subjects divided by the mortality for nonirradiated subjects, was estimated. After adjustment for the effect of interval of observation, age, stage, and class, the RDR estimate is 1.5 but does not differ significantly from unit (95% confidence limits: 0.59, 3.7).
作者开展了一项研究，旨在评估以下假说：在霍奇金淋巴瘤（HD）治疗中对心脏进行照射与冠心病（CHD）死亡率增加相关。本报告描述了1942年至1975年间确诊为HD的957例患者，并分析了截至1977年12月的随访结果。已观察到25例冠心病死亡病例，累积了4258.2人年的风险暴露经验。计算了相对死亡率（RDR），其定义为心脏受照射受试者的冠心病死亡率除以未受照射受试者的死亡率。在对观察间隔、年龄、分期和分级的影响进行校正后，RDR估计值为1.5，但与1无显著差异（95%置信区间：0.59，3.7）。
