Simonsson B, Terenius L, Nilsson K
Cancer. 1982 Jun 15;49(12):2493-6. doi: 10.1002/1097-0142(19820615)49:12<2493::aid-cncr2820491214>3.0.co;2-b.
The cytoplasmic glucocorticoid-receptor (GR) content was analyzed in peripheral leukocytes from 52 nonselected patients with chronic lymphocytic leukemia (CLL). Forty-six patients had measurable GR levels. Six patients lacking measurable GR and seven of eight patients with a low GR content had inactive disease. However, there was no significant difference in average GR content between patients with progressive or nonprogressive disease. Twelve GR-positive patients were treated with prednisolone as the sole medication. Seven patients responded, some in several treatment sessions. There was no correlation between GR-content and clinical response. Thus, in our experience, cytoplasmic GR measurement has only limited predictive value.
分析了52例未经挑选的慢性淋巴细胞白血病（CLL）患者外周血白细胞中的细胞质糖皮质激素受体（GR）含量。46例患者GR水平可测。6例GR水平不可测的患者以及8例GR含量低的患者中有7例疾病呈惰性。然而，疾病进展或非进展患者的平均GR含量无显著差异。12例GR阳性患者接受泼尼松龙单药治疗。7例患者有反应，部分患者在多个疗程后出现反应。GR含量与临床反应之间无相关性。因此，根据我们的经验，细胞质GR检测的预测价值有限。
