Simonsson B, Terenius L, Nilsson K
Scand J Haematol. 1978 Nov;21(5):390-5. doi: 10.1111/j.1600-0609.1978.tb00384.x.
The effect of treatment with prednisolone on clinical and laboratory variables was studied in 6 patients with chronic lymphocytic leukaemia (CLL). The laboratory variables analyzed on the leukaemic cells were surface immunoglobulin (S-Ig), sheep red blood cell receptors (SRBC), proliferative activity (PI) and glucocorticoid receptor (GR). In all cases the CLL was of B-cell type and the leukaemic cells contained a significant amount of GR. 4 out of 6 patients had a progressive disease with increased PI. On treatment they went into clinical remission, which was paralleled by a reduction in the leukaemic B-cell number and in PI. The amount of GR was unaffected. In 2 patients with nonprogressive disease, prednisolone produced no clearcut effect on clinical or laboratory variables.
在6例慢性淋巴细胞白血病（CLL）患者中研究了泼尼松龙治疗对临床和实验室指标的影响。对白血病细胞分析的实验室指标包括表面免疫球蛋白（S-Ig）、绵羊红细胞受体（SRBC）、增殖活性（PI）和糖皮质激素受体（GR）。所有病例的CLL均为B细胞型，白血病细胞含有大量GR。6例患者中有4例病情进展，PI升高。治疗后他们进入临床缓解期，同时白血病B细胞数量和PI降低。GR的量未受影响。在2例病情无进展的患者中，泼尼松龙对临床或实验室指标未产生明显影响。
