Schenk H, Haralambus I, Leb G, Pickel H, Goebel R
MMW Munch Med Wochenschr. 1977 Jul 15;119(28):941-4.
The effect of various hormonal contraceptives on the thyroid hormone level, plasmatic and thrombocytic coagulation, cholesterol and ceruloplasmin levels and the activity of gamma-glutamyl transpeptidase was investigaged by the changes produced by long term cyclic estrogen-gestagen therapy on the metabolism of the organism. The free thyroxine index and the total cholesterol were within the normal range. The thyroxine binding index at 44% was above the normal level and the mean value was significantly raised. The ceruloplasmin concentration in the serum was also significantly increased. Pointers to a general hypercoagulability could not be ascertained with a statistical significance.
通过长期周期性雌激素 - 孕激素疗法对机体代谢产生的变化,研究了各种激素避孕药对甲状腺激素水平、血浆和血小板凝血、胆固醇和铜蓝蛋白水平以及γ-谷氨酰转肽酶活性的影响。游离甲状腺素指数和总胆固醇在正常范围内。甲状腺素结合指数为44%,高于正常水平,且平均值显著升高。血清铜蓝蛋白浓度也显著增加。未发现具有统计学意义的一般高凝性指标。