Turner D A, Von Behren P L, Ruggie N T, Hauser R G, Denes P, Ali A, Messer J V, Fordham E W, Groch M W
Circulation. 1982 Jun;65(7):1511-8. doi: 10.1161/01.cir.65.7.1511.
Least-square phase analysis (LSPA) of radionuclide cineangiograms demonstrates the sequence of onset of inward ventricular movement noninvasively. To validate the method and explore its ability to identify abnormal initial sites of ventricular activation, LSPA was applied to 14 patients with pacemakers (one with electrodes in two locations) (group 1) and three patients with recurrent ventricular tachycardia (VT) (group 2) who had undergone electrophysiologic endocardial mapping. The segment in which the site of initial ventricular activation was located was correctly identified in 13 of 15 paced studies and in two of three group 2 patients during VT. Pacing increased the duration of spread of onset of inward ventricular movement, and the duration of spread of onset correlated well with the duration of the QRS (r = 0.80). The sequence of onset of inward ventricular movement during VT was similar to the sequence of depolarization in all three group 2 patients. These preliminary results suggest that the sequence of onset of ventricular contraction as depicted by LSPA is a valid representation of the actual contraction sequence and that LSPA or radionuclide cineangiography correctly identifies abnormal sites of initial ventricular activation.
放射性核素心血管造影的最小二乘相位分析（LSPA）可无创地显示心室内向运动的起始顺序。为验证该方法并探索其识别心室激活异常起始部位的能力，将LSPA应用于14例植入起搏器的患者（1例电极置于两个部位）（第1组）和3例复发性室性心动过速（VT）患者（第2组），这些患者均接受了心内膜电生理标测。在15次起搏研究中的13次以及第2组3例患者中的2例VT发作期间，正确识别出了心室初始激活部位所在的节段。起搏增加了心室内向运动起始传播的持续时间，且起始传播持续时间与QRS波持续时间相关性良好（r = 0.80）。在所有3例第2组患者中，VT期间心室内向运动的起始顺序与去极化顺序相似。这些初步结果表明，LSPA所描绘的心室收缩起始顺序是实际收缩顺序的有效体现，且LSPA或放射性核素心血管造影能够正确识别心室激活的异常起始部位。
