Small P, Barrett D, Biskin N, Champlin E
Clin Allergy. 1982 Mar;12(2):131-6. doi: 10.1111/j.1365-2222.1982.tb01631.x.
Of 231 patients evaluated for chronic urticaria and angioedema (CUA), 192 were diagnosed as having an idiopathic condition. The roles of serum IgE, complement (CH50), and immune complexes (IC) were investigated in 112 patients with idiopathic CUA. Immediate skin tests were not helpful, but total IgE was elevated in 13%, equally divided between dermographic (D) and non-dermographic (ND) patients. Depressed haemolytic complement (CH50) was noted in 10% of CUA, all of whom were D. Serum IC were elevated in 38% equally divided between D and ND patients. There was no relationship between depressed CH50 and elevated IC. Skin biopsies, evaluated by both light and immunofluorescent techniques, were negative for all specimens tested. The pathophysiology of idiopathic CUA is multifactorial, with a variety of immunological mechanisms involving serum IgE, CH50, and IC. . The relationship between depressed CH50 and dermographism was noted but unexplained by serum or tissue studies.
在对231例慢性荨麻疹和血管性水肿（CUA）患者进行评估时，192例被诊断为特发性疾病。对112例特发性CUA患者研究了血清IgE、补体（CH50）和免疫复合物（IC）的作用。即刻皮肤试验无帮助，但13%的患者总IgE升高，在皮肤划痕症（D）患者和非皮肤划痕症（ND）患者中各占一半。10%的CUA患者溶血补体（CH50）降低，均为D型患者。38%的患者血清IC升高，在D型患者和ND型患者中各占一半。CH50降低与IC升高之间无相关性。采用光镜和免疫荧光技术评估的皮肤活检标本，所有检测标本均为阴性。特发性CUA的病理生理学是多因素的，涉及血清IgE、CH50和IC的多种免疫机制。观察到CH50降低与皮肤划痕症之间的关系，但血清或组织研究无法解释其原因。
