二氢速甾醇-2血清浓度在骨质疏松症和甲状旁腺功能减退症治疗中的应用
Serum concentrations of dihydrotachysterol-2 in the treatment of osteoporosis and hypoparathyroidism.
作者信息
Bosch R, Thijssen J H, Duursma S A
出版信息
Clin Endocrinol (Oxf). 1982 Mar;16(3):295-301. doi: 10.1111/j.1365-2265.1982.tb00719.x.
Abstract
A method for the quantitative estimation of dihydrotachysterol-2 is described using high performance liquid chromatography coupled to an UV monitor. Since radioactive labelled DHT2 is not available, recovery is based on the assumption that dihydrotachysterol-2 and cholecalciferol behave identically during chromatic procedures. Evidence is presented to support this assumption. In patients treated with DHT2 the serum concentrations of DHT2 rose in proportion to the administered dose.
摘要
描述了一种使用高效液相色谱与紫外监测器联用定量估算二氢速甾醇-2的方法。由于没有放射性标记的二氢速甾醇-2，回收率基于二氢速甾醇-2和胆钙化醇在色谱过程中表现相同的假设。提供了证据来支持这一假设。在用二氢速甾醇-2治疗的患者中，二氢速甾醇-2的血清浓度与给药剂量成比例升高。
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