Hata T, Ogihara T, Maruyama A, Mikami H, Nakamaru M, Naka T, Kumahara Y, Nugent C A
Clin Exp Hypertens A. 1982;4(3):341-54. doi: 10.3109/10641968209060747.
We examined the role of dietary electrolytes and humoral factors in causing seasonal changes in blood pressure. Normal subjects had no seasonal difference in blood pressure, although urinary sodium and norepinephrine were significantly higher in winter than in summer. In patients with essential hypertension blood pressure, urinary sodium and norepinephrine excretion and plasma norepinephrine concentration were significantly higher in winter. Plasma renin activity, plasma and urinary aldosterone and urinary kallikrein excretion were not significantly different between the two seasons in both normal subjects and hypertensive patients. In conclusions, the blood pressure of patients with essential hypertension has a seasonal variation with higher pressures in the winter than in the summer. Increased sympathetic nervous activity and an increased load of sodium presented to the kidney for excretion may be contributing factors in the rise in blood pressure in winter in patients with essential hypertension.
我们研究了膳食电解质和体液因素在导致血压季节性变化中所起的作用。正常受试者的血压没有季节性差异，尽管冬季尿钠和去甲肾上腺素水平显著高于夏季。在原发性高血压患者中，冬季血压、尿钠和去甲肾上腺素排泄量以及血浆去甲肾上腺素浓度均显著升高。正常受试者和高血压患者在两个季节之间血浆肾素活性、血浆和尿醛固酮以及尿激肽释放酶排泄量均无显著差异。总之，原发性高血压患者的血压存在季节性变化，冬季血压高于夏季。交感神经活动增加以及肾脏排泄的钠负荷增加可能是原发性高血压患者冬季血压升高的促成因素。
