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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Wagstaff M, Worwood M, Jacobs A

Clin Sci (Lond). 1982 May;62(5):529-40. doi: 10.1042/cs0620529.

The ferritin content of iron-overloaded tissues was higher than that of normal tissues. There was also an increased iron content of ferritin extracted from these tissues. 2. In the limited number of tissues that we examined haemosiderin deposition appeared to be greater in the iron-overloaded livers than in the iron-overloaded spleens. 3. Ferritins extracted from iron-overloaded liver, spleen and kidney had similar properties to those extracted from the corresponding normal tissues. 4. Ferritin from iron-overloaded heart had a greater proportion of more basic isoferritins than had ferritin from normal heart. 5. Immunoreactivity to heart and spleen ferritin antibodies, subunit composition, iron content and rate of iron uptake of both unfractionated ferritin and isoferritin fractions separated by ion exchange chromatography were related to the isoelectric point.

铁过载组织中的铁蛋白含量高于正常组织。从这些组织中提取的铁蛋白的铁含量也有所增加。2. 在我们检查的有限数量的组织中，铁过载肝脏中的含铁血黄素沉积似乎比铁过载脾脏中的更大。3. 从铁过载的肝脏、脾脏和肾脏中提取的铁蛋白与从相应正常组织中提取的铁蛋白具有相似的性质。4. 铁过载心脏中的铁蛋白比正常心脏中的铁蛋白含有更大比例的碱性更强的异铁蛋白。5. 未分级铁蛋白和通过离子交换色谱分离的异铁蛋白组分对心脏和脾脏铁蛋白抗体的免疫反应性、亚基组成、铁含量和铁摄取速率与等电点有关。

Wagstaff M, Worwood M, Jacobs A

Clin Sci (Lond). 1982 May;62(5):529-40. doi: 10.1042/cs0620529.

The ferritin content of iron-overloaded tissues was higher than that of normal tissues. There was also an increased iron content of ferritin extracted from these tissues. 2. In the limited number of tissues that we examined haemosiderin deposition appeared to be greater in the iron-overloaded livers than in the iron-overloaded spleens. 3. Ferritins extracted from iron-overloaded liver, spleen and kidney had similar properties to those extracted from the corresponding normal tissues. 4. Ferritin from iron-overloaded heart had a greater proportion of more basic isoferritins than had ferritin from normal heart. 5. Immunoreactivity to heart and spleen ferritin antibodies, subunit composition, iron content and rate of iron uptake of both unfractionated ferritin and isoferritin fractions separated by ion exchange chromatography were related to the isoelectric point.

铁过载组织中的铁蛋白含量高于正常组织。从这些组织中提取的铁蛋白的铁含量也有所增加。2. 在我们检查的有限数量的组织中，铁过载肝脏中的含铁血黄素沉积似乎比铁过载脾脏中的更大。3. 从铁过载的肝脏、脾脏和肾脏中提取的铁蛋白与从相应正常组织中提取的铁蛋白具有相似的性质。4. 铁过载心脏中的铁蛋白比正常心脏中的铁蛋白含有更大比例的碱性更强的异铁蛋白。5. 未分级铁蛋白和通过离子交换色谱分离的异铁蛋白组分对心脏和脾脏铁蛋白抗体的免疫反应性、亚基组成、铁含量和铁摄取速率与等电点有关。