Bekheit S G, Ali A A, Deglin S M, Jain A C
Chest. 1982 May;81(5):620-5. doi: 10.1378/chest.81.5.620.
Analysis of QT interval from repeated recordings was made in 56 patients with documented idiopathic mitral valve prolapse (IMVP). The results were compared with a control of 62 healthy volunteers in whom mitral valve prolapse was excluded by both phonocardiography and echocardiography and with two other standard populations, those of Simonson and co-workers and of Ashman. After correction for age, the maximum QT interval of the patients with IMVP exceeded the 97.5 percentile of Simonson population in 51 of 56 patients compared with only three of 62 subjects of the control group. The difference between the QT interval of patients from the upper limits of the predicted mean values of Simonson was significant (P less than 0.002). The mean QTC interval in patients with IMVP was 0.48 +/- 0.035 second compared with 0.038 +/- 0.025 second in the control subjects. The difference between the mean QTC interval in patients with IMVP and the control subjects was significant (P less than 0.005). Spontaneous prolongation in the mean QT interval was noted in 43 of 56 patients with IMVP (76.6 percent) compared with only two of 62 control subjects (3 percent). The incidence of episodic arrhythmias was 72 percent in patients with marked QTC prolongation (mean, 0.58 second) compared with 22.6 percent in patients with lesser degree of QTC prolongation (mean, 0.46 second). The results suggest that QT abnormality is common in patients with IMVP and may play an important role in the genesis of cardiac arrhythmia.
对56例确诊为特发性二尖瓣脱垂（IMVP）的患者的重复心电图记录进行QT间期分析。将结果与62名健康志愿者的对照组进行比较，这些志愿者通过心音图和超声心动图排除了二尖瓣脱垂，还与另外两个标准人群，即西蒙森及其同事和阿什曼的人群进行比较。校正年龄后，56例IMVP患者中，有51例的最大QT间期超过了西蒙森人群的97.5百分位数，而对照组62名受试者中只有3例超过。IMVP患者的QT间期与西蒙森预测平均值上限之间的差异具有统计学意义（P<0.002）。IMVP患者的平均QTC间期为0.48±0.035秒，而对照组为0.038±0.025秒。IMVP患者与对照组的平均QTC间期差异具有统计学意义（P<0.005）。56例IMVP患者中有43例（76.6%）出现平均QT间期自发性延长，而62名对照组受试者中只有2例（3%）出现。QTC明显延长（平均0.58秒）的患者中，发作性心律失常的发生率为72%，而QTC延长程度较轻（平均0.46秒）的患者中，这一发生率为22.6%。结果表明，QT异常在IMVP患者中很常见，可能在心律失常的发生中起重要作用。
