Chiu H C, Hsieh K H, Hung T P, Young M C
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1982 Feb;15(1):30-7.
Humoral and cell-mediated immunities were studied in 50 epileptic patients receiving phenytoin treatment and in 20 normals. The mean serum concentrations of IgG, IgA and IgM showed no significant difference between these two groups; however, abnormally low serum IgA (less than 125 mg/dl) was found in 10 patients (10/50, 20%) and in one of them serum IgA was less than 50 mg/dl (1/50, 2%). The serum IgA was related neither to the duration of phenytoin therapy nor to the serum concentration of the drug. The mean serum C3 value was lower in the patient group than in the normals. The mean percentages of T cells, Tmu cells, T gamma cells and monocytes were also lower in the patients, especially in those with serum level of phenytoin over 20 micrograms/ml. These data indicate that phenytoin can suppress the cell-mediated immunity, whereas certain genetic factors, in addition to the effect of phenytoin, may contribute to the change of serum immunoglobulin levels in the epileptics. The incidence of positive antinuclear antibody among the epileptics was 18%, which was much higher than that in the general population. The occurrence of autoantibody did not correlate with the serum concentration of phenytoin.
对50例接受苯妥英治疗的癫痫患者和20名正常人的体液免疫和细胞介导免疫进行了研究。两组患者的血清IgG、IgA和IgM平均浓度无显著差异；然而，10例患者（10/50，20%）血清IgA异常低（低于125mg/dl），其中1例血清IgA低于50mg/dl（1/50，2%）。血清IgA与苯妥英治疗持续时间及药物血清浓度均无关。患者组血清C3均值低于正常组。患者的T细胞、Tμ细胞、Tγ细胞和单核细胞平均百分比也较低，尤其是苯妥英血清水平超过20μg/ml的患者。这些数据表明，苯妥英可抑制细胞介导免疫，而除苯妥英作用外，某些遗传因素可能导致癫痫患者血清免疫球蛋白水平的变化。癫痫患者抗核抗体阳性率为18%，远高于普通人群。自身抗体的出现与苯妥英血清浓度无关。
