Aarli J A
Acta Neurol Scand. 1976 Nov;54(5):423-30. doi: 10.1111/j.1600-0404.1976.tb04374.x.
Immunoglubulin concentrations were determined by radial immunodiffusion in sera from 15 epileptic patients before and during phenytoin therapy. Three reaction patterns were recorded: Two patients developed IgA deficiency (less than 0.05 mg/ml) during the first 3-4 months of treatment. Both patients also had a decrease in serum IgG and IgM, but no significant fall or increase in serum IgE. The IgA deficiency state was apparently reversible, since normalization of serum levels occurred after withdrawal of phenytoin. Five patients developed a 35-80 per cent reduction in serum IgA. In these patients, the decline in serum levels of IgG and IgM was inconsistent. Eight patients showed no significant fluctuations in serum immunoglobulins during phenytoin treatment. When a fall in serum IgA occurred, it did not correspond to a fall in serum or in red cell folate. Mean serum IgG was lower (9.37 mg/ml) in epileptic patients who had taken phenytoin for less than 1 year and had a low IgA, than in patients who had taken phenytoin for 10 years or more (11.50 mg/ml).
采用放射免疫扩散法测定了15例癫痫患者在苯妥英治疗前及治疗期间血清中的免疫球蛋白浓度。记录到三种反应模式：两名患者在治疗的前3 - 4个月出现IgA缺乏（低于0.05mg/ml）。这两名患者的血清IgG和IgM也均下降，但血清IgE无明显下降或升高。IgA缺乏状态显然是可逆的，因为停用苯妥英后血清水平恢复正常。五名患者血清IgA降低了35% - 80%。在这些患者中，血清IgG和IgM水平的下降并不一致。八名患者在苯妥英治疗期间血清免疫球蛋白无明显波动。当血清IgA下降时，它与血清或红细胞叶酸的下降并不对应。服用苯妥英不到1年且IgA水平低的癫痫患者，其平均血清IgG（9.37mg/ml）低于服用苯妥英10年或更长时间的患者（11.50mg/ml）。
