Muhrer K H, Schwemmle K, Filler D, Kahle M
Chirurg. 1982 Feb;53(2):112-6.
Specificity of cellular immunity was verified by the cell migration inhibition test in 36 patients with colorectal cancer and 15 with colorectal adenomas. The electrophoretic mobility test is considered as an indirect method for demonstrating cellular immunity against malignant tumors. Soluble potassium chloride tumor extracts from various human carcinomas were used as antigens. In 31 of 36 tumor patients, a specific lymphocytic sensitization against antigens of colorectal carcinomas could be shown. Lymphocytic reactions to antigens from histologically different tumors (cross-reactions) were weaker or negative. This reaction, verified for carcinomas, was also noted in cases with precancerous lesions. Measurements in 54 healthy control persons with the same antigenic substances showed negative results in 48 cases. Acute inflammatory lesions of the colon reduce the reliability of the test.
通过细胞迁移抑制试验，在36例结直肠癌患者和15例结直肠腺瘤患者中验证了细胞免疫的特异性。电泳迁移率试验被认为是一种间接方法，用于证明针对恶性肿瘤的细胞免疫。来自各种人类癌症的可溶性氯化钾肿瘤提取物用作抗原。在36例肿瘤患者中的31例中，可显示出对结直肠癌抗原的特异性淋巴细胞致敏。对组织学上不同肿瘤的抗原的淋巴细胞反应（交叉反应）较弱或为阴性。这种在癌症中得到验证的反应，在癌前病变病例中也有发现。用相同抗原物质对54名健康对照者进行检测，48例结果为阴性。结肠的急性炎症病变会降低检测的可靠性。
