Wolfsdorf J I, Sadeghi-Nejad A, Senior B
Eur J Pediatr. 1982 Feb;138(1):28-31. doi: 10.1007/BF00442324.
A shortage of alanine for gluconeogenesis is believed responsible for various forms of hypoglycemia and in particular ketotic hypoglycemia (KH). We examined the glucose-alanine relationship in two groups of fasting children, 18 with KH and 44 controls. Glucose levels declined in both groups but significantly more in KH; to 1.98 +/- 0.20 versus 3.26 +/-0.13 mM (mean +/- SEM; P less than 0.001). Alanine also fell in both groups, the concentrations correlating significantly with the concomitant glucose levels (KH: r = 0.64, P less than 0.001, and controls: r = 0.50, P less than 0.001). The relationship of alanine to glucose gave virtually identical regression equations, y = 0.054x + 0.063 for KH and y = 0.054x + 0.050 for controls. The differences in alanine levels between the two groups were too small to account for the greater decline in glucose in KH. The results indicate that hypoalaninemia rather than causing hypoglycemia results from it.
人们认为，糖异生过程中丙氨酸的缺乏是导致各种低血糖症的原因，尤其是酮症性低血糖症（KH）。我们研究了两组禁食儿童的葡萄糖 - 丙氨酸关系，其中18名患有KH，44名作为对照。两组的葡萄糖水平均下降，但KH组下降得更显著；分别降至1.98±0.20毫摩尔/升和3.26±0.13毫摩尔/升（平均值±标准误；P<0.001）。两组的丙氨酸水平也都下降，其浓度与同时的葡萄糖水平显著相关（KH组：r = 0.64，P<0.001；对照组：r = 0.50，P<0.001）。丙氨酸与葡萄糖的关系得出几乎相同的回归方程，KH组为y = 0.054x + 0.063，对照组为y = 0.054x + 0.050。两组之间丙氨酸水平的差异太小，无法解释KH组中葡萄糖下降幅度更大的现象。结果表明，低丙氨酸血症不是导致低血糖症的原因，而是由低血糖症引起的。
