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酮症儿童的血清游离氨基酸消耗

Serum free amino acid depletion in ketotic children.

作者信息

Hayashi M, Konishi K, Kameoka A, Mino M

出版信息

J Nutr Sci Vitaminol (Tokyo). 1981;27(5):449-54. doi: 10.3177/jnsv.27.449.

DOI:10.3177/jnsv.27.449
PMID:7320770
Abstract

Changes in serum free amino acids as a response to ketogenic provocative test were studied in children with a history of ketosis but without hypoglycemia. 1. Of the 17 children who underwent the provocative test, only three showed clinical manifestations. They were among five children who responded to the test and developed hypoglycemia. 2. Hypoglycemic and non-hypoglycemic children differed greatly in the decrement of serum total gluconeogenic amino acids after completion of the test due to the relatively lower levels before provocation in the hypoglycemic group and the inversely higher levels in the non-hypoglycemic group. 3. Gluconeogenic amino acids that decreased sharply after the test were glycine, alanine, glutamine and glutamate.

摘要

对有酮症病史但无低血糖症的儿童进行了研究,以观察血清游离氨基酸作为对生酮激发试验的反应的变化。1. 在接受激发试验的17名儿童中,只有3名出现了临床表现。他们在对试验有反应并发生低血糖的5名儿童之中。2. 低血糖组和非低血糖组儿童在试验完成后血清总糖异生氨基酸的减少量上有很大差异,这是因为低血糖组激发前水平相对较低,而非低血糖组则相反较高。3. 试验后急剧下降的糖异生氨基酸是甘氨酸、丙氨酸、谷氨酰胺和谷氨酸。

相似文献

1
Serum free amino acid depletion in ketotic children.酮症儿童的血清游离氨基酸消耗
J Nutr Sci Vitaminol (Tokyo). 1981;27(5):449-54. doi: 10.3177/jnsv.27.449.
2
Ketotic hypoglycemia and hypopituitarism.酮症性低血糖症和垂体功能减退症。
Pediatrics. 1979 Mar;63(3):414-5.
3
Hypoalaninemia: a concomitant of ketotic hypoglycemia.低丙氨酸血症:酮症性低血糖的一个伴随症状。
J Clin Invest. 1972 Jun;51(6):1440-9. doi: 10.1172/JCI106940.
4
Glycemic response to 24-hour fast in normal children and children with ketotic hypoglycemia: II. Hormonal and metabolic changes.
J Pediatr. 1974 Dec;85(6):776-81. doi: 10.1016/s0022-3476(74)80339-2.
5
[Pathogenesis of ketotic hypoglycemia (author's transl)].酮症性低血糖的发病机制(作者译)
Padiatr Padol. 1979;14(1):53-61.
6
Hypoalaninemia and ketotic hypoglycemia: cause or consequence?低丙氨酸血症和酮症性低血糖:是原因还是结果?
Eur J Pediatr. 1982 Feb;138(1):28-31. doi: 10.1007/BF00442324.
7
Altered Serum Amino Acid and Acylcarnitine Profiles in Hyperinsulinemic Hypoglycemia and Ketotic Hypoglycemia.高胰岛素血症性低血糖和酮症性低血糖时血清氨基酸和酰基肉碱谱的改变。
Front Endocrinol (Lausanne). 2020 Oct 8;11:577373. doi: 10.3389/fendo.2020.577373. eCollection 2020.
8
Insulin and glucagon secretion in the ketotic (idiopathic glucagon unresponsive) hypoglycemia of childhood.
J Endocrinol Invest. 1979 Jan-Mar;2(1):51-7. doi: 10.1007/BF03349275.
9
[Intermittent branched--chain ketoacidurie in ketotic hypoglycemia: investigations to localize the biochemical defect (author's transl)].
Monatsschr Kinderheilkd (1902). 1976 Feb;124(2):59-65.
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The concentration of free amino acids in blood serum of dairy cows with primary ketosis.患有原发性酮病的奶牛血清中游离氨基酸的浓度。
Pol J Vet Sci. 2018 Mar;21(1):149-156. doi: 10.24425/119033.

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