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氟化钠对离体小鼠胃H⁺离子分泌的刺激作用。

Stimulation of H+ ion secretion from the isolated mouse stomach by sodium fluoride.

作者信息

Assem E S, Wan B Y

出版信息

Experientia. 1982 Mar 15;38(3):369-70. doi: 10.1007/BF01949398.

DOI:10.1007/BF01949398
PMID:7075733
Abstract

The effect of sodium fluoride on H+ ion secretion was investigated in the isolated distended mouse stomach. It was found that sodium fluoride on its own caused dose-related stimulation of H+ ion secretion. Sodium fluoride did not inhibit H+ ion secretion induced by histamine. The possible mechanisms involved are discussed. It is considered that sodium fluoride might stimulate H+ ion secretion by causing histamine release and by increasing cyclic AMP formation in the intact gastric mucosa.

摘要

在离体扩张的小鼠胃中研究了氟化钠对氢离子分泌的影响。发现氟化钠自身可引起与剂量相关的氢离子分泌刺激。氟化钠并不抑制组胺诱导的氢离子分泌。文中讨论了可能涉及的机制。认为氟化钠可能通过引起组胺释放以及增加完整胃黏膜中环磷酸腺苷的形成来刺激氢离子分泌。

相似文献

1
Stimulation of H+ ion secretion from the isolated mouse stomach by sodium fluoride.氟化钠对离体小鼠胃H⁺离子分泌的刺激作用。
Experientia. 1982 Mar 15;38(3):369-70. doi: 10.1007/BF01949398.
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The effcts of sodium fluoride on gastric acid and electrolyte output in the anaesthetized cat.氟化钠对麻醉猫胃酸和电解质分泌的影响。
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Effect of fluoride on the intestinal epithelial cell brush border membrane.氟化物对肠上皮细胞刷状缘膜的影响。

本文引用的文献

1
The effect of sodium fluoride on the output of some electrolytes from the gastric mucosa of cats.氟化钠对猫胃黏膜某些电解质分泌的影响。
J Physiol. 1956 Aug 28;133(2):317-29. doi: 10.1113/jphysiol.1956.sp005588.
2
The effect of sodium fluoride on gastric acid secretion.氟化钠对胃酸分泌的影响。
J Physiol. 1953 Oct;122(1):203-8. doi: 10.1113/jphysiol.1953.sp004992.
3
The effcts of sodium fluoride on gastric acid and electrolyte output in the anaesthetized cat.氟化钠对麻醉猫胃酸和电解质分泌的影响。
Bull Environ Contam Toxicol. 1987 Jul;39(1):162-7. doi: 10.1007/BF01691805.
J Physiol. 1980 Apr;301:39-48. doi: 10.1113/jphysiol.1980.sp013186.
4
Effects of anticholinesterases and of sodium fluoride on neuromyal desensitization.抗胆碱酯酶和氟化钠对神经肌肉脱敏的影响。
Neuropharmacology. 1980 Apr;19(4):393-403. doi: 10.1016/0028-3908(80)90192-6.
5
Role of fatty acid oxidation in mechanism of action of gastric secretagogues.
Am J Physiol. 1980 Mar;238(3):G255-62. doi: 10.1152/ajpgi.1980.238.3.G255.
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Metabolic inhibitors and catecholamine-stimulated lipolysis.
Biochem Pharmacol. 1967 Aug;16(8):1439-46. doi: 10.1016/0006-2952(67)90119-0.
7
Inhibition of cholinesterases by fluoride in vitro.氟化物在体外对胆碱酯酶的抑制作用。
Biochem J. 1966 Apr;99(1):133-7. doi: 10.1042/bj0990133.
8
Action of fluoride on cholinesterase. II. In vitro reactivation of cholinesterases inhibited by organophosphorous compounds.氟化物对胆碱酯酶的作用。II. 被有机磷化合物抑制的胆碱酯酶的体外复活
Biochem Pharmacol. 1965 Sep;14(9):1363-73. doi: 10.1016/0006-2952(65)90120-6.
9
Effect of fluoride on the metabolic activity of thyroid slices.氟对甲状腺切片代谢活性的影响。
Endocrinology. 1968 Jul;83(1):157-60. doi: 10.1210/endo-83-1-157.
10
Effect of sodium fluoride on cyclic AMP production in rat hepatocytes.氟化钠对大鼠肝细胞中环磷酸腺苷生成的影响。
J Cyclic Nucleotide Res. 1979;5(1):43-53.