Sergeev P V, Belykh A G
Farmakol Toksikol. 1982 Mar-Apr;45(2):96-100.
Radiographic contrast agents (RCA) cause a profound and long-term blockade of iodine-absorption thyroid function. It was ascertained that the thyroid gland binds both iodine that splits off from a RCA and the agent itself. The changes were found in 125I-iodine binding by the thyroid gland after preadministering the hepatotropic poison CCl4 and the liver function stimulant phenobarbital. Antithyroid action of RCA is accounted for the interaction of the thyroid gland with native molecules of RCA and by their deiodination in the liver.
放射造影剂（RCA）会导致碘吸收甲状腺功能的深度和长期阻滞。已确定甲状腺会结合从RCA中分离出的碘以及造影剂本身。在预先给予亲肝毒物四氯化碳和肝功能刺激剂苯巴比妥后，发现甲状腺对125I碘的结合发生了变化。RCA的抗甲状腺作用是由于甲状腺与RCA天然分子的相互作用以及它们在肝脏中的脱碘作用。
