消胆胺和活性炭对格列吡嗪吸收的影响。
The effect of cholestyramine and activated charcoal on glipizide absorption.
作者信息
Kivistö K T, Neuvonen P J
机构信息
Department of Pharmacology, University of Turku, Finland.
出版信息
Br J Clin Pharmacol. 1990 Nov;30(5):733-6. doi: 10.1111/j.1365-2125.1990.tb03843.x.
Abstract
- The interference of cholestyramine and activated charcoal with the absorption of glipizide was studied. 2. In a cross-over study comprising three phases, single doses of cholestyramine (8 g), activated charcoal (8 g) or water only were given to six healthy volunteers together with a single dose of glipizide. 3. The absorption of glipizide was moderately (29%, P less than 0.01) reduced by cholestyramine and greatly reduced (81%, P less than 0.01) by activated charcoal. 4. If cholestyramine and glipizide are used concomitantly, glipizide should be taken 1-2 h beforehand. In acute glipizide overdosage, activated charcoal can be used to reduce absorption.
摘要
- 研究了消胆胺和活性炭对格列吡嗪吸收的干扰作用。2. 在一项包含三个阶段的交叉研究中，给6名健康志愿者分别单次服用消胆胺（8克）、活性炭（8克）或仅用水，同时给予单次剂量的格列吡嗪。3. 消胆胺使格列吡嗪的吸收适度降低（29%，P<0.01），而活性炭使其大幅降低（81%，P<0.01）。4. 如果同时使用消胆胺和格列吡嗪，格列吡嗪应提前1 - 2小时服用。在急性格列吡嗪过量时，可使用活性炭来减少吸收。
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