Nádvorníková H, Schück O
Int J Clin Pharmacol Ther Toxicol. 1982 Apr;20(4):155-8.
The effect of intranasal administration of 10 micrograms of 1-deamino-8-d-arginine vasopressin (DDAVP) and intravenous administration of 200 micrograms of N-glycyl-glycyl-glycyl-lysin-vasopressin (TGLVP) on urinary concentration (UK) and fractional excretion (FEK) of potassium was investigated in healthy subjects. For comparison the same parameters were followed under conditions of 36-h water-intake restriction. Once the maximally concentrated urine had been reached, the average value of UK after DDAVP administration was 108 +/- 45 mmol/l and after TGLVP administration 102 +/- 48 mmol/l. These values are significantly higher (p less than 0.001) than the average value of UK observed under conditions of water deprivation (58 +/- 22 mol/l). The average value of FEK after DDAVP administration was 14.8 +/- 6.3% and after TGLVP administration, 14.9 +/- 6.5%. These values are also significantly higher (p less than 0.001) than the average values of FEK observed under control conditions (9.3 +/- 5.5%) The effect of DDAVP on UK and FEK was related to the age of the investigated subjects. The most pronounced changes were observed in younger individuals. The influence of vasopressin analogs on UK and FEK could not be explained on the basis of changes in urinary osmolarity, sodium excretion, or fractional water excretion. The results obtained are compatible with the hypothesis that DDAVP and TGLVP increase the tubular secretion of potassium. The mechanism of action has to be elucidated by further research.
在健康受试者中，研究了经鼻给予10微克1-去氨基-8-D-精氨酸加压素（DDAVP）和静脉给予200微克N-甘氨酰-甘氨酰-甘氨酰-赖氨酸加压素（TGLVP）对尿钾浓度（UK）和钾排泄分数（FEK）的影响。为作比较，在36小时限水条件下观察相同参数。一旦达到最大浓缩尿，给予DDAVP后UK的平均值为108±45 mmol/L，给予TGLVP后为102±48 mmol/L。这些值显著高于（p<0.001）禁水条件下观察到的UK平均值（58±22 mmol/L）。给予DDAVP后FEK的平均值为14.8±6.3%，给予TGLVP后为14.9±6.5%。这些值也显著高于（p<0.001）对照条件下观察到的FEK平均值（9.3±5.5%）。DDAVP对UK和FEK的影响与被研究受试者的年龄有关。在较年轻个体中观察到最明显的变化。血管加压素类似物对UK和FEK的影响不能根据尿渗透压、钠排泄或水排泄分数的变化来解释。所得结果与DDAVP和TGLVP增加肾小管钾分泌的假说相符。其作用机制有待进一步研究阐明。
