Skopková J, Hrbas R, Barth T
Endocrinol Exp. 1981;15(2):129-38.
The relation between the duration of antidiuresis and sodium excretion and the route of administration of [8-lysine-vasopressin or [8-D-arginine]-deaminovasopressin to conscious rats was investigated. Both compounds were administered either intravenously through a chronically inserted catheter in the right jugular vein, or subcutaneously. The rats were then placed into individual metabolic cages and urine was collected quantitatively. Subcutaneous administration of both compounds resulted in a more prolonged antidiuretic response, lower sodium excretion and higher total urine osmolality. In order to achieve a comparable half-time antidiuresis, it was necessary to apply about 1000 times higher does of [8-lysine]vasopressin than those of [8D-arginine]deaminovasopressin. The relation between the duration of both antidiuresis and sodium excretion and the way of administration was, however, more pronounced in the case of [8-lysine]vasopressin. The excretion of potassium was increased after both compounds, the highest value being found after subcutaneous administration of [8-lysine]vasopressin.
研究了抗利尿持续时间和钠排泄与向清醒大鼠注射[8-赖氨酸-血管加压素]或[8-D-精氨酸]-脱氨加压素的给药途径之间的关系。两种化合物均通过右颈静脉长期插入的导管静脉注射或皮下注射。然后将大鼠放入单独的代谢笼中，定量收集尿液。两种化合物皮下给药均导致抗利尿反应延长、钠排泄降低和总尿渗透压升高。为了获得相当的抗利尿半衰期，[8-赖氨酸]血管加压素的给药剂量必须比[8D-精氨酸]脱氨加压素高约1000倍。然而，对于[8-赖氨酸]血管加压素，抗利尿持续时间和钠排泄与给药方式之间的关系更为明显。两种化合物给药后钾排泄均增加，皮下注射[8-赖氨酸]血管加压素后钾排泄值最高。
