Chandra S R, Ernest J T, Goldstick T K
Invest Ophthalmol Vis Sci. 1982 Jun;22(6):783-7.
The effect of panretinal photocoagulation on ocular blood flow was studied in pigmented rabbits by means of labeled microsphere impaction and in monkeys by indocyanine-green-dye clearance. In the rabbits, one eye of each animal was photocoagulated and the follow eye of the same animal was used as the control. Twenty-six rabbits received full-scatter panretinal photocoagulation (300 +/- 20 burns, one half burn apart) and an additional 32 rabbits received partial-scatter panretinal photocoagulation (150 +/- 20 burns, one burn apart). After full-scatter photocoagulation there was a significant decrease in choroidal-retinal blood flow measured at 1 to 2 hr, 24 hr, 2 weeks, 4 weeks, and 3 months, but no change in iris-ciliary body blood flow. After partial scatter photocoagulation there was no consistent change. In one monkey, 100 burns were placed around the macular area and in a second monkey 100 burns were placed in the inferior half of the ocular fundus. Choroidal blood flow was significantly reduced in both monkeys for the initial hour during which is was continually measured.
通过标记微球撞击法在色素兔中研究了全视网膜光凝对眼血流的影响，并通过吲哚菁绿染料清除法在猴中进行了研究。在兔中，每只动物的一只眼睛接受光凝，而同一只动物的另一只眼睛用作对照。26只兔接受了全散射全视网膜光凝（300±20个光斑，光斑间距为半个光斑），另外32只兔接受了部分散射全视网膜光凝（150±20个光斑，光斑间距为1个光斑）。全散射光凝后，在1至2小时、24小时、2周、4周和3个月时测量的脉络膜-视网膜血流显著减少，但虹膜-睫状体血流无变化。部分散射光凝后没有一致的变化。在一只猴中，在黄斑区周围进行了一百次光斑照射，在另一只猴中，在眼底下半部进行了一百次光斑照射。在持续测量的最初一小时内，两只猴的脉络膜血流均显著减少。
