Engström C, Linde A, Thilander B
J Anat. 1982 Mar;134(Pt 2):299-314.
The influence of a low calcium and vitamin D-deficient diet on the growth and form of the skull of the growing rat was studied using a cephalometric radiographic technique. First, this technique was used to obtain an intra-individual cephalometric description of the normal growth and form of the skull at different ages during postnatal growth in the rat. It was shown that the methodological error and the biological variation between animals were significantly lower than the registered growth changes, thus demonstrating the suitability of the technique. In the animals fed the low calcium and vitamin D-deficient diet and impaired increase in body weight was found. This diet also caused changes in cranial dimensions, both when the deficient animals were compared with control animals of the same age and with control animals with the same weight. It was concluded that the vitamin D-free and low calcium diet caused a disturbed osteogenesis in growth sites determining the growth and form of the viscerocranium and its relation to the neurocranium.
采用头颅测量放射技术研究了低钙和维生素D缺乏饮食对生长中大鼠颅骨生长和形态的影响。首先，该技术用于对大鼠出生后生长不同阶段颅骨的正常生长和形态进行个体内头颅测量描述。结果表明，方法误差和动物间的生物学变异显著低于所记录的生长变化，从而证明了该技术的适用性。在喂食低钙和维生素D缺乏饮食的动物中，发现体重增加受损。当将缺乏该饮食的动物与相同年龄的对照动物以及相同体重的对照动物进行比较时，这种饮食也会导致颅骨尺寸的变化。得出的结论是，无维生素D和低钙饮食在决定面颅骨生长和形态及其与脑颅骨关系的生长部位导致了成骨紊乱。
