左旋多巴治疗帕金森病：一项十年随访研究。
L-dopa treatment of Parkinson's disease: a ten-year follow up study.
作者信息
Bauer R B, Stevens C, Reveno W S, Rosenbaum H
出版信息
J Am Geriatr Soc. 1982 May;30(5):322-5. doi: 10.1111/j.1532-5415.1982.tb05621.x.
A ten-year follow-up study of parkinsonian patients treated with L-dopa is presented. Originally 130 patients entered the study, and previous reports were presented in 1971 and 1973. This report concerns the 47 remaining patients now available for examination. The effectiveness of L-dopa diminished over the ten-year period, so that the disability states of these patients are now similar to those prevailing just before the study began ten years ago. Despite the decline, the interim improvement and the patients' relatively asymptomatic existence for part of the time confirm the effectiveness of L-dopa therapy in the treatment of Parkinson's disease.
本文呈现了一项对接受左旋多巴治疗的帕金森病患者进行的十年随访研究。最初有130名患者进入该研究，此前的报告分别发表于1971年和1973年。本报告涉及目前可供检查的47名剩余患者。在这十年期间，左旋多巴的疗效逐渐降低，以至于这些患者目前的残疾状态与十年前研究开始前普遍存在的状态相似。尽管疗效有所下降，但中期的改善以及患者在部分时间内相对无症状的状态证实了左旋多巴疗法在治疗帕金森病方面的有效性。
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