Rozen P, Gelfond M, Salzman S, Baron J, Gilat T
J Clin Gastroenterol. 1982 Feb;4(1):17-22. doi: 10.1097/00004836-198202000-00003.
In fifteen patients with achalasia, we measured lower esophageal sphincter pressures before and after 5 mg of sublingual isosorbide dinitrate. The mean pressure fell significantly, from 36.5 to 18.4 mm Hg (P less than 0.01). The effectiveness of this therapy was confirmed by gamma camera measurement of the esophageal emptying time of a radionuclide test meal which was significantly less after the medication (P less 0.05). The emptying time was invariably longer than 10 minutes before therapy, and in 12 of the 15 patients decreased after therapy to 1-8 minutes, corresponding to the clinical response to the drug therapy. The noninvasive radionuclide technique provides a simple way of assessing the results of drug therapy in achalasia.
在15例贲门失弛缓症患者中，我们测量了5毫克舌下含服硝酸异山梨酯前后的食管下括约肌压力。平均压力显著下降，从36.5毫米汞柱降至18.4毫米汞柱（P小于0.01）。通过γ相机测量放射性核素试验餐的食管排空时间来证实该疗法的有效性，用药后食管排空时间显著缩短（P小于0.05）。治疗前排空时间总是超过10分钟，15例患者中有12例治疗后降至1 - 8分钟，这与药物治疗的临床反应相符。非侵入性放射性核素技术为评估贲门失弛缓症药物治疗的效果提供了一种简单方法。
