Johnson K M
J Neural Transm. 1982;53(2-3):179-86. doi: 10.1007/BF01243409.
Acute administration of phencyclidine hydrochloride (PCP) resulted in a dose-responsive decrease in the conversion of 3H-tryptophan to 3H-serotonin (3H-5-HT) in rat forebrain. Subsequent experiments measured the effect of a subthreshold dose of PCP (4 mg/kg) daily for one, seven, or four-teen days on this index of 5-HT turnover. Although single administration again had no effect at this dose, repeated administration for seven days resulted in a 37% decrease in 5-HT turnover. However, after fourteen days of administration this index was not significantly different from saline controls The possible significance of these findings are discussed in relation to reported alterations in PCP-induced behaviors observed with chronic administration.
急性给予盐酸苯环己哌啶（PCP）会导致大鼠前脑中3H-色氨酸向3H-血清素（3H-5-HT）的转化呈剂量依赖性降低。随后的实验测量了每天给予阈下剂量的PCP（4mg/kg），持续1天、7天或14天对该5-HT周转指标的影响。尽管单次给药在该剂量下再次无作用，但连续给药7天导致5-HT周转降低了37%。然而，给药14天后，该指标与生理盐水对照组无显著差异。结合慢性给药时观察到的PCP诱导行为的报道变化，讨论了这些发现的可能意义。
