苯环利定对单胺能神经元自发活动的影响。
Effects of phencyclidine on the spontaneous activity of monoaminergic neurons.
作者信息
Raja S N, Guyenet P G
出版信息
Eur J Pharmacol. 1980 May 2;63(2-3):229-33. doi: 10.1016/0014-2999(80)90452-5.
PMID:7379857
Abstract
Intravenous phencyclidine (PCP) increased the firing rate of a population of slow firing dopaminergic neurons recorded in the substantia nigra of chloral hydrate anesthetized rats. PCP also significantly reduced the potency of i.v. d-amphetamine to inhibit the firing of dopaminergic neurons. The drug produced little changes in the activity of serotonergic neurons of the dorsal raphe and consistently inhibited the firing of noradrenergic neurons in the locus coeruleus.
摘要
静脉注射苯环己哌啶（PCP）可提高水合氯醛麻醉大鼠黑质中一群慢发放多巴胺能神经元的放电频率。PCP还显著降低了静脉注射右旋苯丙胺抑制多巴胺能神经元放电的效力。该药物对中缝背核5-羟色胺能神经元的活动几乎没有影响，并持续抑制蓝斑中去甲肾上腺素能神经元的放电。
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