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大鼠脑中苯乙酸的鉴定与分布

Identification and distribution of phenylacetic acid in the brain of the rat.

作者信息

Durden D A, Boulton A A

出版信息

J Neurochem. 1982 Jun;38(6):1532-6. doi: 10.1111/j.1471-4159.1982.tb06629.x.

DOI:10.1111/j.1471-4159.1982.tb06629.x
PMID:7077324
Abstract

Phenylacetic acid, the major metabolite of phenylethylamine, has been identified and quantitated in rat brain regions by capillary column high-resolution gas chromatography mass spectrometry. Its distribution is heterogeneous and correlates with that of phenylethylamine. The values obtained were (ng/g +/- SEM): whole brain, 31.2 +/- 2.7; caudate nucleus, 64.6 +/- 6.5; hypothalamus, 60.1 +/- 7.4; cerebellum, 31.3 +/- 2.9; brainstem, 33.1 +/- 3.3, and the "rest," 27.6 +/- 3.0.

摘要

苯乙酸是苯乙胺的主要代谢产物,已通过毛细管柱高分辨率气相色谱质谱法在大鼠脑区中进行了鉴定和定量。其分布不均一,且与苯乙胺的分布相关。得到的值为(纳克/克±标准误):全脑,31.2±2.7;尾状核,64.6±6.5;下丘脑,60.1±7.4;小脑,31.3±2.9;脑干,33.1±3.3,以及“其余部分”,27.6±3.0。

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Identification and distribution of phenylacetic acid in the brain of the rat.大鼠脑中苯乙酸的鉴定与分布
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