Durden D A, Boulton A A
J Neurochem. 1981 Jan;36(1):129-35. doi: 10.1111/j.1471-4159.1981.tb02387.x.
The m and p isomers of hydroxyphenylacetic acid have been identified and quantitated in whole rat brain and in several regions using a capillary column high resolution gas chromatography - mass spectrometry procedure. Their concentrations were: for m-hydroxyphenylacetic acid (mean +/- S.E., number of determinations in parentheses)-whole brain, 2.3 +/- 0.3 ng/g (7); hypothalamus, 1.2 +/- 0.3 ng/g (5); caudate nucleus, 5.5 +/- 0.6 ng/g (5); brain stem, 1.8 +/- 0.1 ng/g (5); cerebellum, 1.2 +/- 0.1 ng/g (5) and the "rest," 1.7 +/- 0.1 ng/g (5); and for p-hydroxyphenylacetic acid-whole brain, 10.6 +/- 0.7 ng/g (7); hypothalamus, 4.5 +/- 0.1 ng/g (4); caudate nucleus, 28.3 +/- 1.6 ng/g (5); brain stem, 8.6 +/- 0.6 ng/g (5); cerebellum, 8.1 +/- 0.4 ng/g (5), and the "rest," 5.3 +/- 0.5 ng/g (5). This heterogeneous distribution parallels closely that exhibited by their respective precursor amines, m- and p-tyramine.
已使用毛细管柱高分辨率气相色谱 - 质谱法在全大鼠脑及几个脑区中鉴定并定量了羟基苯乙酸的间位和对位异构体。它们的浓度如下：间羟基苯乙酸（平均值±标准误，括号内为测定次数）——全脑，2.3±0.3 ng/g（7次）；下丘脑，1.2±0.3 ng/g（5次）；尾状核，5.5±0.6 ng/g（5次）；脑干，1.8±0.1 ng/g（5次）；小脑，1.2±0.1 ng/g（5次）以及“其余部分”，1.7±0.1 ng/g（5次）；对羟基苯乙酸——全脑，10.6±0.7 ng/g（7次）；下丘脑，4.5±0.1 ng/g（4次）；尾状核，28.3±1.6 ng/g（5次）；脑干，8.6±0.6 ng/g（5次）；小脑，8.1±0.4 ng/g（5次），以及“其余部分”，5.3±0.5 ng/g（5次）。这种异质性分布与它们各自相应的前体胺，即间位和对位酪胺所呈现的分布密切相似。
