Puri P, Guiney E J
J Pediatr Surg. 1982 Feb;17(1):22-4. doi: 10.1016/s0022-3468(82)80319-9.
Two consecutive short gut babies with a residual small intestinal length of 44 and 46 cm, respectively, were managed initially by total parenteral nutrition and oral feedings begun around the fifth week postoperatively. Uncontrollable diarrhea, malabsorption, and failure to thrive made the early management of these babies a difficult problem. The two infants developed clinical features of hypothyroidism at the age of 4 and 6 mo, respectively. Hypothyroxinemia was confirmed by repeated detection of low serum levels of T4. Hormonal treatment resulted in clinical recovery and normalized T4 values. Thyroid function has remained normal after discontinuation of treatment, underlining the transient nature of hypothyroidism. Early recognition and therapy of this previously unreported association is essential in order to prevent mental retardation.
两名连续的短肠患儿，剩余小肠长度分别为44厘米和46厘米，最初通过全胃肠外营养进行治疗，并在术后约第五周开始口服喂养。无法控制的腹泻、吸收不良和生长发育不良使这些患儿的早期管理成为一个难题。这两名婴儿分别在4个月和6个月大时出现了甲状腺功能减退的临床特征。通过反复检测低血清T4水平确诊为低甲状腺素血症。激素治疗使临床症状恢复，T4值恢复正常。停药后甲状腺功能一直保持正常，突出了甲状腺功能减退的短暂性。为了预防智力迟钝，早期识别和治疗这种以前未报告的关联至关重要。
