Hisaoka M, Tsukada K, Morioka T
J Pharmacobiodyn. 1982 Jan;5(1):27-33. doi: 10.1248/bpb1978.5.27.
To examine the possibility of utilizing liposomes as drug carriers of carboquone (CQ), an antitumor agent, effects of encapsulation on transport into lymphatics have been studied. Enhancement of lymphatic transport of CQ was obtained by the administration of liposome encapsulated CQ (CQ-liposome) into abdominal cavity in thoracic duct cannulated rats. And also, the enhancement of CQ transport into regional lymph nodes belong to gastrointestinal tract was also demonstrated in normal rats. When CQ-liposome was administered intravenously or intramuscularly, however, excellent transport into lymphatics was not recognized. Various pharmaceutical formation such as emulsions and oily solution failed to produce as high a lymph level as CQ-liposome. These results show that liposome may represent an effective system to deliver CQ into lymphatics by intraperitoneal administration.
为了研究将脂质体用作抗肿瘤药物卡波醌（CQ）的药物载体的可能性，已对包封对其向淋巴管转运的影响进行了研究。通过向胸导管插管大鼠的腹腔内注射脂质体包裹的CQ（CQ-脂质体），可增强CQ在淋巴管中的转运。此外，在正常大鼠中也证实了CQ向胃肠道所属区域淋巴结的转运增强。然而，当静脉内或肌肉内注射CQ-脂质体时，未观察到其向淋巴管的良好转运。各种药物制剂，如乳剂和油溶液，未能产生与CQ-脂质体一样高的淋巴水平。这些结果表明，脂质体可能是一种通过腹腔内给药将CQ递送至淋巴管的有效系统。
