Vassilev T L
Allergy. 1978 Jun;33(3):155-9. doi: 10.1111/j.1398-9995.1978.tb01527.x.
The ability of aluminium phosphate and calcium phosphate to stimulate the synthesis of tetanus toxoid-specific anaphilactic and antitoxic antibodies is compared. The observed differences in the kinetics of IgG1a, IgG1b and antitoxines are quantitative--titres after application of aluminium phosphate are higher. Booster immunization with aluminium but not calcium phosphate-adsorbed toxoid leads to a prolonged synthesis of specific IgE. It is hypothesized that the regular application of aluminium compound-containing vaccines on the entire population could be one of the factors leading to the observed increase of allergic diseases.
比较了磷酸铝和磷酸钙刺激破伤风类毒素特异性过敏反应性抗体和抗毒素抗体合成的能力。观察到的IgG1a、IgG1b和抗毒素动力学差异是定量的——应用磷酸铝后的效价更高。用吸附了铝而非磷酸钙的类毒素进行加强免疫会导致特异性IgE的合成延长。据推测，在整个人口中常规使用含铝化合物疫苗可能是导致观察到的过敏性疾病增加的因素之一。
