Horwood S P, Boyle M H, Torrance G W, Sinclair J C
Pediatrics. 1982 May;69(5):613-20.
All very low-birth-weight infants live-born to residents of an urban southern Ontario county were studied before (1964 to 1969) and after (1973 to 1977) the introduction of neonatal intensive care. Mortality at hospital discharge decreased from 89.4% to 77.6% among infants whose birth weights were 500 to 999 gm and from 37.6% to 22.8% among infants with birth weights of 1,000 to 1,499 gm. The families of 121/150 (81%) and 134/151 (89%) of all children from the two cohorts who were discharged from the hospital alive were surveyed. At follow-up 7/121 (6%) and 4/134 (4%) had died. Major damage was reported for 13/121 (11%) and 18/134 (13%) of the children. Neonatal intensive care was associated with a significant reduction in mortality but there has not been a significant change in morbidity.
对安大略省南部一个城市县的居民所生的所有极低出生体重活产婴儿在新生儿重症监护引入之前（1964年至1969年）和之后（1973年至1977年）进行了研究。出生体重在500至999克的婴儿出院时死亡率从89.4%降至77.6%，出生体重在1000至1499克的婴儿死亡率从37.6%降至22.8%。对两个队列中所有存活出院儿童的121/150（81%）和134/151（89%）的家庭进行了调查。随访时，7/121（6%）和4/134（4%）的儿童死亡。据报告，13/121（11%）和18/134（13%）的儿童有严重损伤。新生儿重症监护与死亡率显著降低相关，但发病率没有显著变化。
