Richer G, Jansen F K, Gros P
Nouv Presse Med. 1982 Apr 10;11(17):1321-4.
Immunotoxins are hybrid molecules made up of an antibody and of the toxic subunit of a polypeptidic toxin. They act on the principle that the antibody binds the molecule to a cellular antigen which it specifically recognizes, so that the cytotoxic component only kills those cells that bear the antigen. Cell hybridizations obtained by fusion now produce monoclonal antibodies specific enough to bind the antigens present on certain malignant cells. In vitro experiments have demonstrated the high specific activity of immunotoxins against malignant cells, and this seems to be confirmed by in vivo experiments in mice. Such experimental results suggest that immunotoxins may eventually be used in the treatment of cancer as well as for other pharmacological purposes.
免疫毒素是由抗体和多肽毒素的毒性亚基组成的杂合分子。它们的作用原理是抗体将分子与它特异性识别的细胞抗原结合，从而使细胞毒性成分只杀死那些带有该抗原的细胞。通过融合获得的细胞杂交现在产生了特异性足以结合某些恶性细胞上存在的抗原的单克隆抗体。体外实验已经证明了免疫毒素对恶性细胞具有高特异性活性，并且这似乎在小鼠体内实验中得到了证实。这些实验结果表明，免疫毒素最终可能用于癌症治疗以及其他药理学目的。
