去乙酰化促黑素细胞激素（Des-acetyl MSH）和γ-促黑素细胞激素（gamma-MSH）在绿安乐蜥的黑素细胞上作为α-促黑素细胞激素（alpha-MSH）的部分激动剂起作用。

Des-acetyl MSH and gamma-MSH act as partial agonists to alpha-MSH on the Anolis melanophore.

作者信息

McCormack A M, Carter R J, Thody A J, Shuster S

出版信息

Peptides. 1982 Jan-Feb;3(1):13-6. doi: 10.1016/0196-9781(82)90134-6.

Abstract

The biological activities of alpha-MSH des-acetyl MSH, gamma-MSH and LPH37-58 were compared using the Anolis rate method of bioassay. Dose-response data showed LPH37-58 to be equipotent with alpha-MSH, but des-acetyl MSH and gamma-MSH were found to be much less active. The effect of LPH37-58 was additive to that of alpha-MSH, indicating that LPH37-58 is a full agonist of alpha-MSH. The lower potency peptides des-acetyl MSH and gamma-MSH reduced the effect of alpha-MSH and are, therefore, partial agonists of alpha-MSH. The action of MSH peptides in vivo may be modulated by interaction with agonists.

摘要

使用变色蜥生物测定法比较了α-促黑素、去乙酰基促黑素、γ-促黑素和促脂解素37-58的生物活性。剂量反应数据表明促脂解素37-58与α-促黑素等效，但发现去乙酰基促黑素和γ-促黑素的活性要低得多。促脂解素37-58的作用与α-促黑素的作用相加，表明促脂解素37-58是α-促黑素的完全激动剂。活性较低的肽去乙酰基促黑素和γ-促黑素降低了α-促黑素的作用，因此是α-促黑素的部分激动剂。促黑素肽在体内的作用可能通过与激动剂的相互作用来调节。