Kurek M, Consbruch U
Pharmacopsychiatria. 1982 Mar;15(2):65-9. doi: 10.1055/s-2007-1019511.
A follow-up of patients under lithium-prophylaxis in a psychiatric neurological practice over a period of eight years is presented. It allowed for the evaluation of the therapeutic results of 54 of a total of 65 patients with affective psychoses. 32 patients remained free from any further episodes of illness (average duration of treatment 3.8 years). In another 14 patients (average duration of treatment 2.9 years) further episodes occurred but with obviously milder symptomatics. 8 patients (average duration of treatment 4.5 years) had to be considered as non-responders. This result largely consists with reports by other authors. Failures were mainly due to non compliance or diagnostic errors. The small number of patients stopping the prophylaxis without approval of the therapist (5 out of 65 patients) may be attributed to a rigid preselection of patients and to the fact that the conditions for a good patient compliance are more favourable in the practice with its tight and continuous doctor - patient relationship than in a typical out-patient department. Intoxications or other lithium-induced complications did not occur. Generally side effects could be well controlled and/or were tolerated by the patients. Discontinuance of therapy due to side effects was necessary in 3 cases.
本文介绍了在一家精神神经科诊所对接受锂盐预防治疗的患者进行的为期八年的随访情况。通过该随访可以评估65例情感性精神病患者中54例的治疗效果。32例患者未再出现任何疾病发作（平均治疗时长3.8年）。另外14例患者（平均治疗时长2.9年）出现了进一步发作，但症状明显较轻。8例患者（平均治疗时长4.5年）被视为无反应者。这一结果在很大程度上与其他作者的报告一致。治疗失败主要是由于不依从或诊断错误。未经治疗师批准就停止预防治疗的患者数量较少（65例患者中有5例），这可能归因于对患者的严格预选，以及在该诊所紧密且持续的医患关系下，患者依从性良好的条件比典型门诊更有利。未发生中毒或其他锂盐引起的并发症。一般来说，副作用能够得到很好的控制和/或患者能够耐受。有3例因副作用而不得不停止治疗。
