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糖尿病小鼠的夹尾行为与镇痛作用

Tail pinch behavior and analgesia in diabetic mice.

作者信息

Levine A S, Morley J E, Wilcox G, Brown D M, Handwerger B S

出版信息

Physiol Behav. 1982 Jan;28(1):39-43. doi: 10.1016/0031-9384(82)90098-1.

DOI:10.1016/0031-9384(82)90098-1
PMID:7079321
Abstract

Mild tail pinch induced "consummatory" behaviors in mice. The major tail pinch behavior appeared to be chewing with food ingestion occurring possibly as an epiphenomenon. All tail pinch behaviors were obliterated by the dopamine antagonist haloperidol; and the opiate antagonist, naltrexone, decreased eating without altering chewing. The combination of dopamine blockade and tail pinch induced jumping behavior in mice. Diabetic mice showed increased tail flick latencies to radiant heat and to the induction of tail pinch behaviors, displaying these behaviors less commonly than their homozygote and heterozygote littermate controls.

摘要

轻度尾部夹捏会诱发小鼠的“ consummatory”行为。主要的尾部夹捏行为似乎是咀嚼,食物摄取可能是一种附带现象。所有尾部夹捏行为都被多巴胺拮抗剂氟哌啶醇消除;而阿片拮抗剂纳曲酮减少了进食,但没有改变咀嚼行为。多巴胺阻断与尾部夹捏的组合在小鼠中诱发了跳跃行为。糖尿病小鼠对辐射热和尾部夹捏行为诱导的甩尾潜伏期增加,表现出这些行为的频率低于其纯合子和杂合子同窝对照。

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Tail pinch behavior and analgesia in diabetic mice.糖尿病小鼠的夹尾行为与镇痛作用
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