Levine A S, Wilcox G L, Grace M, Morley J E
Physiol Behav. 1982 Jun;28(6):959-62. doi: 10.1016/0031-9384(82)90160-3.
Pinching the tail of a rat results in a set of consummatory behaviors including chewing, eating and licking. In the present study, the effect of tail pinch on pain thresholds was evaluated using the hot-plate and writhing tests. Continuous tail pinch resulted in chewing and markedly lengthened the latency to hind-paw licking and jumping (hot-plate test) when compared with control rats and totally eliminated writhing behaviors. Tail pinch (which induced chewing) for one minute prior to the analgesic testing also prolonged the latency of hot plate-induced behaviors and suppressed the number of writhing behaviors. Naloxone reversed the tail pinch induced analgesia as measured by the hot-plate test, but did not reverse tail pinch-induced analgesia as measured by the writhing test.
捏大鼠尾巴会引发一系列包括咀嚼、进食和舔舐在内的终结性行为。在本研究中，使用热板法和扭体试验评估了捏尾巴对痛阈的影响。与对照大鼠相比，持续捏尾巴会导致咀嚼，并显著延长后爪舔舐和跳跃的潜伏期（热板法试验），并完全消除扭体行为。在镇痛测试前捏尾巴一分钟（这会引发咀嚼）也会延长热板法诱导行为的潜伏期，并抑制扭体行为的次数。纳洛酮可逆转热板法试验所测的捏尾巴诱导的镇痛作用，但不能逆转扭体试验所测的捏尾巴诱导的镇痛作用。
