Romsos D R, Ferguson D
Physiol Behav. 1982 Feb;28(2):301-5. doi: 10.1016/0031-9384(82)90079-8.
Obese mice, self-selecting from three food cups containing carbohydrate, fat and protein supplemented with minerals and vitamins, selected the same proportion of energy from protein (approximately 20%) as did lean mice. Young obese mice also selected the same proportion of carbohydrate and fat as selected by lean mice, but adult obese mice self-selected a higher proportion of energy from fat and a lower proportion from carbohydrate than did lean mice. The high preference by adult obese mice for fat was confirmed in additional studies employing two food cups, one containing a high-carbohydrate diet and the other a high-fat diet. We speculate that the preference by adult obese mice for fat is related to their insulin resistance.
肥胖小鼠从三个分别装有碳水化合物、脂肪和补充了矿物质及维生素的蛋白质的食物杯中自行选择食物，它们从蛋白质中摄取的能量比例（约20%）与瘦小鼠相同。年轻的肥胖小鼠选择的碳水化合物和脂肪比例也与瘦小鼠相同，但成年肥胖小鼠自行选择从脂肪中摄取的能量比例高于瘦小鼠，从碳水化合物中摄取的能量比例低于瘦小鼠。在另外两项研究中，使用两个食物杯，一个装有高碳水化合物饮食，另一个装有高脂肪饮食，证实了成年肥胖小鼠对脂肪的高度偏好。我们推测成年肥胖小鼠对脂肪的偏好与它们的胰岛素抵抗有关。
