Gupta B N, Linden R J, Mary D A, Weatherill D
Q J Exp Physiol. 1982 Apr;67(2):235-58. doi: 10.1113/expphysiol.1982.sp002633.
The diuretic and natriuretic responses to stimulation of atrial receptors were compared in two groups of anaesthetized dogs, one group with a high blood volume and another group with a low blood volume. A diuretic response to stimulation of the atrial receptors was obtained in the two groups of animals. Both the diuretic and the natriuretic responses to stimulation of the atrial receptors were greater in the dogs with high blood volume than in the dogs with low blood volume. In a second series of experiments, a diuretic response to stimulation of the atrial receptors was demonstrated in both groups of animals following surgical denervation of the kidney. In the denervated kidney, a large increase in heart rate, associated with stimulation of the atrial receptors, significantly contributed to the diuretic response in the dogs with high blood volume but not to the response in dogs with low blood volume. In the denervated kidney, a natriuretic response was only obtained in the dogs with high blood volume in which a large increase in heart rate was associated with stimulation of the atrial receptors. The present results show that the diuretic and natriuretic responses to stimulation of atrial receptors are greater in dogs with high blood volume than in dogs with low blood volume, and that increases in heart rate, associated with stimulation of atrial receptors, significantly contribute to the diuretic and natriuretic responses in acutely denervated kidneys in the dogs with high blood volume.
在两组麻醉犬中比较了心房受体受刺激后的利尿和排钠反应，一组血容量高，另一组血容量低。两组动物均出现了心房受体受刺激后的利尿反应。血容量高的犬心房受体受刺激后的利尿和排钠反应均比血容量低的犬更强。在第二系列实验中，两组动物在肾脏手术去神经支配后均出现了心房受体受刺激后的利尿反应。在去神经支配的肾脏中，与心房受体受刺激相关的心率大幅增加，对血容量高的犬的利尿反应有显著贡献，但对血容量低的犬的反应无显著贡献。在去神经支配的肾脏中，仅在血容量高且心房受体受刺激时心率大幅增加的犬中出现了排钠反应。目前的结果表明，血容量高的犬心房受体受刺激后的利尿和排钠反应比血容量低的犬更强，且与心房受体受刺激相关的心率增加，对血容量高的犬急性去神经支配肾脏的利尿和排钠反应有显著贡献。
