Boyd N F, O'Sullivan B, Campbell J E, Fishell E, Simor I, Cooke G, Germanson T
Radiology. 1982 Jun;143(3):671-4. doi: 10.1148/radiology.143.3.7079494.
Wolfe's finding that some mammographic patterns (P2 and DY) are associated with an increased risk of breast cancer has been challenged by some authors who suggest that this is due to denser patterns concealing cancers present on the first examination: these cancers, it is argued, are diagnosed in later years, creating the spurious impression of increased cancer incidence. The authors examined this hypothesis in a series of patients with breast cancer but failed to find any evidence that the diagnosis was subject to systematic delay in patients with the P2 or DY pattern. Moreover, studies of a hypothetical model showed that bias in the detection of breast cancer was unlikely to account for more than a small increase in apparent cancer incidence. Thus it appears unlikely that such a bias is responsible for the risk of breast cancer observed in patients with these mammographic patterns.
沃尔夫发现某些乳房X线摄影模式（P2和DY）与乳腺癌风险增加有关，但一些作者对此提出了质疑，他们认为这是由于密度较高的模式掩盖了首次检查时就已存在的癌症：有人认为，这些癌症在随后几年才被诊断出来，从而造成了癌症发病率增加的虚假印象。作者在一系列乳腺癌患者中检验了这一假设，但未发现任何证据表明P2或DY模式的患者诊断存在系统性延迟。此外，对一个假设模型的研究表明，乳腺癌检测中的偏差不太可能导致明显的癌症发病率增加超过一小部分。因此，这种偏差似乎不太可能是这些乳房X线摄影模式的患者中观察到的乳腺癌风险的原因。
