Loeffler K, Klose-Violette D, Brehm H
Rontgenblatter. 1982 Apr;35(4):151-4.
Arthrography of the knee joint was performed in 12 domestic pigs using Hexabrix (meglumine and sodium ioxaglate). Conray EV (sodium and meglumine iothalamate) was used for comparison. X-ray films were taken at periodic intervals. Hexabrix was found to stay slightly longer in the joints. The animals were sacrificed at 3 different times after injection and the synovial membrane of the knee joints and the joint cartilage of the patella were assessed histologically. 3 of 6 joints showed a strictly limited focus with leukocytes in the fat pad 24 hours after the injection. In the other cases no inflammatory reactions were seen after injection of the contrast media.
使用Hexabrix（碘克沙葡胺）对12只家猪的膝关节进行了关节造影。使用Conray EV（碘他拉葡胺）作为对照。定期拍摄X线片。发现Hexabrix在关节内停留的时间略长。在注射后3个不同时间点处死动物，对膝关节滑膜和髌骨的关节软骨进行组织学评估。注射后24小时，6个关节中有3个在脂肪垫中出现了白细胞聚集的严格局限病灶。在其他情况下，注射造影剂后未观察到炎症反应。
