Schindler A M
Schweiz Med Wochenschr. 1982 Mar 6;112(10):339-44.
The clinical and morphological aspects of occult sclerosing carcinoma of the thyroid are presented on the basis of a ten-year review of the surgically removed thyroids in Geneva and from the study of thyroid glands obtained from 133 consecutive autopsies. The 15 cases found in the surgical material represented 7.7% of all malignant thyroid tumours and one fifth of the papillary carcinomas. Occult tumours are found at a mean age of 46.6 years and predominate in women. Clinically, two thirds presented as nodular goiters, two cases as primary hyperplasia and one as primary hyperparathyroidism. Three out of 15 cases presented clinically with a cervical lymph node metastasis. Treatment was conservative in all cases and consisted of subtotal thyroidectomy and/or elective lymphadenectomy, followed by medical suppression of TSH. Follow-up in 11 cases showed a single recurrence in a cervical lymph node, while the other 10 cases have been disease free for 4 to 13 years. In the autopsy series 3 thyroid glands (2.3%) contained occult tumours, two of which were microcarcinomas. The Genevan series compares with other European and American studies but differs from the much higher incidence in the Japanese.
基于对日内瓦外科切除甲状腺的十年回顾以及对133例连续尸检获得的甲状腺的研究，介绍了隐匿性甲状腺硬化癌的临床和形态学特征。手术材料中发现的15例病例占所有甲状腺恶性肿瘤的7.7%，占乳头状癌的五分之一。隐匿性肿瘤的平均发病年龄为46.6岁，女性居多。临床上，三分之二表现为结节性甲状腺肿，2例表现为原发性增生，1例表现为原发性甲状旁腺功能亢进。15例中有3例临床上出现颈部淋巴结转移。所有病例均采用保守治疗，包括甲状腺次全切除术和/或选择性淋巴结清扫术，随后进行促甲状腺激素的药物抑制治疗。11例随访显示1例颈部淋巴结复发，其他10例无病生存4至13年。在尸检系列中，3个甲状腺（2.3%）含有隐匿性肿瘤，其中2个为微癌。日内瓦系列与其他欧美研究结果相似，但与日本的高得多的发病率不同。
