Humair L
Schweiz Med Wochenschr. 1982 Feb 27;112(9):310-4.
Intravenous bumetanide was tested in patients with cardiac and renal failure with creatinine clearance below 12 ml/min. Water diuresis and natriuresis occur 2 or 3 hours after the injection, this delayed activity of the drug being due to renal insufficiency. The loss of potassium caused by the diuretic is slight. Bumetanide is effective at the level of the Henle loop. The rise in filtered sodium excretion suggests that the drug may have an action on the distal tubule. One patient with pericarditis and terminal renal failure (creatinine clearance 2 ml/min) did not respond to bumetanide.
对肌酐清除率低于12毫升/分钟的心力衰竭和肾衰竭患者进行了静脉注射布美他尼的试验。注射后2至3小时出现水利尿和利钠作用，药物的这种延迟作用是由于肾功能不全所致。利尿剂引起的钾流失轻微。布美他尼在亨利氏袢水平有效。滤过钠排泄的增加表明该药物可能对远曲小管有作用。一名患有心包炎和终末期肾衰竭（肌酐清除率2毫升/分钟）的患者对布美他尼无反应。
