Barry K J, Selland B A, Stein B M
Surg Neurol. 1982 Apr;17(4):273-8. doi: 10.1016/0090-3019(82)90121-5.
The prevalent use of epsilon aminocaproic acid (EACA) to prevent rebleeding in the preoperative management of ruptured intracranial aneurysms raises the question of a relationship between this drug and cerebral vasospasm. The effects of EACA on the contractile properties of the rat common carotid artery were measured in vitro, and the effects of EACA on the catecholamine content of these arteries were determined qualitatively. When carotid artery segments from rats that had been infused with lactated Ringer's solution alone were incubated in the presence of 1 mM EACA, they exhibited a decrease in contractile activity brought about by the presence of either serotonin or norepinephrine, and an increase in contractile activity when potassium chloride was used. These changes were not witnessed if the arterial segments came from rats that had been infused with lactated Ringer's solution containing EACA. No effect of epsilon aminocaproic acid was found on the median effective dose values for each vasoconstrictor used. Fluorescence histochemistry showed no qualitative changes in the catecholamine content of carotid arteries following EACA treatment.
在破裂颅内动脉瘤的术前管理中，普遍使用ε-氨基己酸（EACA）来预防再出血，这引发了该药物与脑血管痉挛之间关系的问题。在体外测量了EACA对大鼠颈总动脉收缩特性的影响，并定性地确定了EACA对这些动脉中儿茶酚胺含量的影响。当仅用乳酸林格氏液灌注的大鼠的颈动脉段在1 mM EACA存在下孵育时，它们在血清素或去甲肾上腺素存在下表现出收缩活性降低，而在使用氯化钾时收缩活性增加。如果动脉段来自用含EACA的乳酸林格氏液灌注的大鼠，则未观察到这些变化。未发现ε-氨基己酸对所用每种血管收缩剂的半数有效剂量值有影响。荧光组织化学显示，EACA处理后颈动脉中儿茶酚胺含量无定性变化。
