Taranenko T M, Stepanov V M, Aikimbaev A M, Kovalev I F, Dernova V S
Antibiotiki. 1978 Oct;23(10):918-22.
Immunochemical analysis of 2 polysaccharide-containing structures of the lypopolysaccharide of the plague causative agent (main somatic antigen and lipopolysaccharide) isolated from K-1 strain and a number of its antibiotic resistant mutants was carried out. It was shown that development of resistance to streptomycin alone or its combination with monomycin did not cause detectable changes in the monosaccharide composition and serological properties of the cultures tested. More significant changes associated with development of complex resistance, i.e. K-1 (Strr leads to Penr leads to Tetr) were accompanied by a decrease in the content of hexozamine and serological activity of the main somatic antigen determining the O-specificity of the lipopolysaccharide. Defective changes in the monosaccharide composition and serological properties of both the main somatic antigen and the polysaccharide were observed in the yellow variant of the streptomycin resistant mutant K-1.
对从K-1菌株及其一些抗生素抗性突变体中分离出的鼠疫病原体脂多糖的2种含多糖结构（主要菌体抗原和脂多糖）进行了免疫化学分析。结果表明，单独对链霉素产生抗性或其与莫能菌素联合使用产生抗性，均未导致受试培养物的单糖组成和血清学特性发生可检测到的变化。与复杂抗性（即K-1（链霉素抗性导致青霉素抗性导致四环素抗性））发展相关的更显著变化伴随着己糖胺含量的降低以及决定脂多糖O特异性的主要菌体抗原的血清学活性的降低。在链霉素抗性突变体K-1的黄色变体中，观察到主要菌体抗原和多糖的单糖组成及血清学特性存在缺陷性变化。
