在给予T-2毒素（某些镰刀菌微真菌的单端孢霉烯次生代谢产物）的大鼠中发现的血压变化和心血管病变。
Blood pressure changes and cardiovascular lesions found in rats given T-2 toxin, a trichothecene secondary metabolite of certain Fusarium microfungi.
作者信息
Wilson C A, Everard D M, Schoental R
出版信息
Toxicol Lett. 1982 Jan;10(1):35-40. doi: 10.1016/0378-4274(82)90264-8.
PMID:7080066
Abstract
White weanling rats were given intragastrically 4 doses of T-2 toxin (3 alpha-hydroxy-4 beta-1,5-diacetoxy-8 alpha-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene) a secondary metabolite of certain Fusarium species, 6 out of 9 treated rats developed increased blood pressure; these animals showed microscopically severe cardiovascular abnormalities. Occasional contamination of foodstuffs wh Fusarium may contribute to hypertension and cardiovascular lesions in animals and man.
摘要
给断乳的白色大鼠经胃内给予4剂T-2毒素（3α-羟基-4β-1,5-二乙酰氧基-8α-（3-甲基丁酰氧基）-12,13-环氧单端孢霉烯-9-烯），它是某些镰刀菌属的一种次生代谢产物，9只接受处理的大鼠中有6只血压升高；这些动物在显微镜下显示出严重的心血管异常。食物偶尔被镰刀菌污染可能导致动物和人类的高血压和心血管病变。
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