Fiegel P, Becker K
Antimicrob Agents Chemother. 1978 Sep;14(3):288-91. doi: 10.1128/AAC.14.3.288.
The pharmacokinetics of azlocillin, a new wide-spectrum antibiotic of the N-substituted group of ureidomethyl penicillins, was investigated in 10 subjects with normal and in 32 subjects with impaired renal functions. After intravenous injection of 2 g of azlocillin, serum concentrations of drug were measured microbiologically. The half-lives of azlocillin were 47 +/- 8.8 min in patients with normal renal function, and 293.3 min in patients with severely impaired renal function. The correlation of half-life to renal functions is shown by the equation: t/2 = 425.03.Cl(In) (-0.4509), where Cl(In) is inulin clearance. The volume of distribution of the azlocillin was 17.7% of the body weight. Protein binding was similar in patients with normal renal function and in those with severely impaired renal functions. The urinary excretion rate of azlocillin in patients with normal renal function was 64.8 +/- 8.8% in 24 h.
对10名肾功能正常的受试者和32名肾功能受损的受试者研究了新型广谱抗生素阿洛西林（一种N-取代脲基甲基青霉素类药物）的药代动力学。静脉注射2g阿洛西林后，采用微生物学方法测定血清药物浓度。阿洛西林在肾功能正常患者中的半衰期为47±8.8分钟，在肾功能严重受损患者中为293.3分钟。半衰期与肾功能的相关性由以下公式表示：t/2 = 425.03.Cl(In) (-0.4509)，其中Cl(In)为菊粉清除率。阿洛西林的分布容积为体重的17.7%。肾功能正常患者和肾功能严重受损患者的蛋白结合情况相似。肾功能正常患者24小时内阿洛西林的尿排泄率为64.8±8.8%。
